Enzastaurin (hydrochloride)
Enzastaurin (LY317615) hydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1][2][3].
Product Specifications
CAS Number
359017-79-1
Product Name Alternative
LY317615 (hydrochloride)
UNSPSC
12352005
Target
Apoptosis; Autophagy; PKC
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enzastaurin-hydrochloride.html
Smiles
O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O.Cl
Molecular Formula
C32H30ClN5O2
Molecular Weight
552.07
References & Citations
[1]Graff JR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res, 2005, 65 (16), |[2]Rovedo MA, et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol, 2011, 131 (7), 1442-1449.|[3]Podar K, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl) . Blood, 2007, 109 (4), 1669-1677.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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