GNE-235

GNE-235 is a compound selective for the second bromodomain of PBRM1, with a KD of 0.28 ± 0.02 μM. GNE-235 can be used for evaluation of the cellular function of PBRM1[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gne-235.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H]1CCCN1C2=C(N)N=NC(C3=CC=CO3)=C2

Molecular Formula

C13H16N4O

Molecular Weight

244.29

References & Citations

[1]Cochran AG, et al. GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. J Med Chem. 2023 Sep 28;66 (18) :13116-13134.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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