BX-912
BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM) . BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis[1].
Product Specifications
CAS Number
[702674-56-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; PDK-1
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BX-912.html
Purity
99.06
Solubility
DMSO : ≥ 100 mg/mL
Smiles
BrC1=C(NCCC2=CNC=N2)N=C(NC3=CC(NC(N4CCCC4)=O)=CC=C3)N=C1
Molecular Formula
C20H23BrN8O
Molecular Weight
471.35
Precautions
H315, H319, H335
References & Citations
[1]Feldman RI, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280 (20) :19867-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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