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RW3

RW3 (MP196) is a small cationic antimicrobial hexapeptide. RW3 targets the bacterial cytoplasmic membrane and inhibits cellular respiration and cell wall synthesis. RW3 exhibits high bioactivity against Gram-positive bacteria such as Bacillus subtilis 168 (MIC of 2 µg/mL) . RW3 causes shrinking of murine erythrocytes. RW3 can be used in antimicrobial and antifungal research[1].

Product Specifications

CAS Number

359632-11-4

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rw3.html

Purity

98.00

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C51H69N19O6

Molecular Weight

1044.22

References & Citations

[1]Wenzel M, et al. Towards profiles of resistance development and toxicity for the small cationic hexapeptide RWRWRW-NH2[J]. Frontiers in Cell and Developmental Biology, 2016, 4: 86.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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