Tofimilast
Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC50 of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP[1].
Product Specifications
CAS Number
185954-27-2
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tofimilast.html
Solubility
10 mM in DMSO
Smiles
CCC1=NN(C2=C1CCN3C2=NN=C3C4=CC=CS4)C5CCCC5
Molecular Formula
C18H21N5S
Molecular Weight
339.46
References & Citations
[1]Duplantier AJ, et al. SAR of a series of 5,6-dihydro- (9H) -pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. J Med Chem. 2007 Jan 25;50 (2) :344-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE4
Available Sizes
Frequently Asked Questions
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