IACS-8803 (diammonium)

IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy[1].

Product Specifications

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/iacs-8803-diammonium.html

Purity

98.79

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O[P@@]4([S-])=O)[C@@H](CO[P@](O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)([S-])=O)O3.[NH4+].[NH4+]

Molecular Formula

C20H29FN12O9P2S2

Molecular Weight

726.60

References & Citations

[1]Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29 (20) :126640.