3-Hydroxypicolinic acid

3-Hydroxypicolinic acid is a matrix. 3-Hydroxypicolinic acid coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) . 3-Hydroxypicolinic acid is useful for nucleic acid analysis and anti-tuberculosis compound development[1][2][3].

Product Specifications

CAS Number

[874-24-8]

Product Name Alternative

3-hydroxypyridine-2-carboxylic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents; Drug Intermediate

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/3-Hydroxypicolinic_acid.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC=CC=C1O)O

Molecular Formula

C6H5NO3

Molecular Weight

139.11

Precautions

H315, H319, H335

References & Citations

[1]Zhou L, et al. A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides. Rapid Commun Mass Spectrom. 2004;18 (7) :787-94.|[2]Brockman FJ, et al. Isolation and characterization of quinoline-degrading bacteria from subsurface sediments. Appl Environ Microbiol. 1989 Apr;55 (4) :1029-32.|[3]do Couto Almeida J, et al. Synthesis, cytotoxic and antitubercular activities of copper (II) complexes with heterocyclic bases and 3-hydroxypicolinic acid. Inorganica Chimica Acta, 2016, 446: 87-92.