2-Hexyl-4-pentynoic acid
Product Specifications
UNSPSC Description
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1]. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
HDAC; HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-hexyl-4-pentynoic-acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCC(CC#C)C(O)=O
Molecular Weight
182.26
References & Citations
[1]Yan Leng, et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neurosci Lett. 2010 Jun 7;476(3):127-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118783/2-Hexyl-4-pentynoic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118783/2-Hexyl-4-pentynoic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
96017-59-3
Available Sizes
Curated Selection
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