1-Methylcytosine

1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine[1][2].

Product Specifications

CAS Number

[1122-47-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-Methylcytosine.html

Concentration

10mM

Purity

99.01

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(C=CN1C)=NC1=O

Molecular Formula

C5H7N3O

Molecular Weight

125.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Kistenmacher, T. J.; Rossi, M. (1977-12-15) . "1-Methylcytosine: a refinement". Acta Crystallographica (1977) Section B. 33 (12) : 3962–3965.|[2]Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363 (6429) :884-887.