[MePhe7]-Neurokinin B
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) [1].
Product Specifications
CAS Number
110880-53-0
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mephe7-neurokinin-b.html
Purity
98.87
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CC(C[C@H](NC(CNC([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CCSC)=O)CC1=CN=CN1)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)C)CC4=CC=CC=C4)=O)=O)C(N[C@H](C(N)=O)CCSC)=O)C
Molecular Formula
C60H81N13O14S2
Molecular Weight
1272.49
References & Citations
[1]Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21 (8) :2413-2417.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK3R
Available Sizes
Frequently Asked Questions
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