[MePhe7]-Neurokinin B

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) [1].

Product Specifications

CAS Number

[110880-53-0]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mephe7-neurokinin-b.html

Purity

98.87

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

CC(C[C@H](NC(CNC([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CCSC)=O)CC1=CN=CN1)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)C)CC4=CC=CC=C4)=O)=O)C(N[C@H](C(N)=O)CCSC)=O)C

Molecular Formula

C60H81N13O14S2

Molecular Weight

1272.49

References & Citations

[1]Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21 (8) :2413-2417.