S-309309

S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research[1].

Product Specifications

CAS Number

[2267352-04-3]

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-309309.html

Purity

98.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=CC2=C1[C@]3(NC(C4=C(NC(CS(C)(=O)=O)=O)N(C5=CC=C(C)C=N5)N=C4C3)=O)CCO2

Molecular Formula

C23H21F2N5O5S

Molecular Weight

517.51

References & Citations

[1]Miyano T, et al. The Continuous and Reversible Transformation of the Polymorphs of an MGAT2 Inhibitor (S-309309) from the Anhydrate to the Hydrate in Response to Relative Humidity. Pharmaceutics. 2024 Jul 17;16 (7) :949.|[2]YOSHIKI RYO, et al. 1649-P: S-309309, a Novel MGAT2 Inhibitor, Enhances Intestinal Fatty Acid Beta Oxidation and Provides Metabolic Benefits in DIO Mice. Diabetes, 2024, 73 (Supplement_1) .