NLRP3-IN-62
NLRP3-IN-62 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-62 inhibits pyroptosis in THP-1 cell with an IC50 of 0.7 nM, inhibits IL-β release with an IC50 of 108.5 nM[1].
Product Specifications
CAS Number
[3059965-71-5]
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-62.html
Smiles
O=C1C=C2C(CN(C2)C3=NC4=NC(C5=C(C=C(C(F)(F)F)C=C5C)O)=CC=C4O3)=CN1
Molecular Formula
C21H15F3N4O3
Molecular Weight
428.36
References & Citations
[1]AITKEN LS, et al., Nlrp3 inhibitors. WO2024213552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6393564-01 0.1 mL
Semaphorin 3D (Semaphorin-3D, SEMA3D, Coll-2, Sema-Z2, UNQ760/PRO1491) APC
Ask
View Details