NLRP3-IN-62
NLRP3-IN-62 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-62 inhibits pyroptosis in THP-1 cell with an IC50 of 0.7 nM, inhibits IL-β release with an IC50 of 108.5 nM[1].
Product Specifications
CAS Number
[3059965-71-5]
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-62.html
Smiles
O=C1C=C2C(CN(C2)C3=NC4=NC(C5=C(C=C(C(F)(F)F)C=C5C)O)=CC=C4O3)=CN1
Molecular Formula
C21H15F3N4O3
Molecular Weight
428.36
References & Citations
[1]AITKEN LS, et al., Nlrp3 inhibitors. WO2024213552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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