NLRP3-IN-62

NLRP3-IN-62 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-62 inhibits pyroptosis in THP-1 cell with an IC50 of 0.7 nM, inhibits IL-β release with an IC50 of 108.5 nM[1].

Product Specifications

CAS Number

[3059965-71-5]

UNSPSC

12352005

Target

NOD-like Receptor (NLR) ; Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-62.html

Smiles

O=C1C=C2C(CN(C2)C3=NC4=NC(C5=C(C=C(C(F)(F)F)C=C5C)O)=CC=C4O3)=CN1

Molecular Formula

C21H15F3N4O3

Molecular Weight

428.36

References & Citations

[1]AITKEN LS, et al., Nlrp3 inhibitors. WO2024213552.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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