TLR8 agonist 8
TLR8 agonist 8 (Compound II-72) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 8 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 [1].
Product Specifications
CAS Number
3034750-58-5
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr8-agonist-8.html
Smiles
O=C(CNC(CCCCCN1C(C=CC1=O)=O)=O)NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(N3CC4=CC(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)=CN=C4CC3)=O)=O)=O
Molecular Formula
C53H63N11O10
Molecular Weight
1014.14
References & Citations
[1]Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8
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