Deoxycholic acid (sodium hydrate)

Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].

Product Specifications

CAS Number

[145224-92-6]

Product Name Alternative

Cholanoic Acid (sodium hydrate) ; Desoxycholic acid (sodium hydrate)

UNSPSC

12352211

Hazard Statement

H302

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/deoxycholic-acid-sodium-hydrate.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C.O

Molecular Formula

C24H41NaO5

Molecular Weight

432.57

Precautions

P264-P270-P330-P501

References & Citations

[1]Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2 (8) . pii: 91809.|[2]Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6 (4) :788-797.