F8I2 rabbit pAb
This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008],
Product Specifications
Background
This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008]
UniProt
P23610
Swiss Prot
P23610
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human F8I2 AA range: 33-83
Target
F8I2
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Early endosome . Nucleus, nuclear body . Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778) . In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity) . Colocalized with HTT in endosomes (PubMed:16476778) . In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity) . .
Gene ID (Human)
474383
Available Sizes
Curated Selection
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