MC4033
Product Specifications
UNSPSC Description
MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1].
MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].
Target Antigen
Apoptosis; Autophagy; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc4033.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=NN(C2=CC=C(C=C2)C(O)=O)C(/C1=C\C3=CC=CN3)=O
Molecular Weight
295.29
References & Citations
[1]Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149302/MC4033-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149302/MC4033-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
28532-21-0
Available Sizes
Curated Selection
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