1-NM-PP1

1-NM-PP1, a cell-permeable PP1 analog, is a potent Src family kinases inhibitor with IC50s of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively[1][2].

Product Specifications

CAS Number

[221244-14-0]

Product Name Alternative

PP1 Analog II

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-NM-PP1.html

Purity

99.17

Solubility

DMSO : 27.5 mg/mL (ultrasonic; warming)

Smiles

CC(N1N=C(CC2=CC=CC3=C2C=CC=C3)C4=C(N)N=CN=C41)(C)C

Molecular Formula

C20H21N5

Molecular Weight

331.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Bishop A C, et al. Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach. Journal of the American Chemical Society, 1999, 121 (4) :627-631.|[2]Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407 (6802) :395-401.|[3]Larochelle S, et al. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell. 2007 Mar 23;25 (6) :839-50.