Fumagillin

Fumagillin (NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

Product Specifications

CAS Number

[23110-15-8]

Product Name Alternative

Amebacilin; NSC9168

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; HIV; Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fumagillin.html

Purity

99.0

Solubility

DMSO : 142.86 mg/mL (ultrasonic)

Smiles

C[C@]1([C@@H](C/C=C(C)/C)O1)[C@]([C@@H]2OC)([H])[C@]3(CC[C@H]2OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)CO3

Molecular Formula

C26H34O7

Molecular Weight

458.54

Precautions

H302

References & Citations

[1]Lefkove, B., B. Govindarajan, and J.L. Arbiser, Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther, 2007. 5 (4) : p. 573-9.|[2]Watanabe N, et al. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580 (11) :2598-602.