GNE-9278
GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD) . GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].
Product Specifications
CAS Number
[2315311-83-0]
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gne-9278.html
Purity
99.89
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(N=C2CCC)C(N2)=NC(C)=C1N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O
Molecular Formula
C21H27N5O3S
Molecular Weight
429.54
References & Citations
[1]Wang TM, et, al. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. . 2017 Jul 15; 121: 204-218.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Curated Selection
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