GNE-9278

GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD) . GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].

Product Specifications

CAS Number

[2315311-83-0]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gne-9278.html

Purity

99.89

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(N=C2CCC)C(N2)=NC(C)=C1N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O

Molecular Formula

C21H27N5O3S

Molecular Weight

429.54

References & Citations

[1]Wang TM, et, al. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. . 2017 Jul 15; 121: 204-218.