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RP-182-PEG3-K (palmitic acid)

RP-182-PEG3-K palmitic acid (Compound 1a) is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K palmitic acid inhibits CD206high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K palmitic acid exhibits antitumor efficacy in mouse B16 melanoma allografts[1].

Product Specifications

UNSPSC

12352209

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rp-182-peg3-k-palmitic-acid.html

Smiles

C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CC=CC=C1)=O)CCCNC(N)=N)=O)CCCCN)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCCOCCOCCOCC(N[C@H](C(N)=O)CCCCNC(CCCCCCCCCCCCCCC)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O

Molecular Formula

C99H161N23O16

Molecular Weight

1929.48

References & Citations

[1]Singh SS, et al., Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity. Mol Cancer Ther. 2024 Aug 30.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

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