Anti-GPR15/BOB Antibody

Rabbit Polyclonal Antibody specific to GPR15 (NT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Brother of Bonzo, BoB

Gene Name

GPR15

Gene ID

2838

NCBI Gene ID

UniProt

P49685

Accession Number

NP_005281

Cellular Locus

Cell membrane; Multi-pass membrane protein.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 13- 28 of human GPR15. This sequence differs from those of African green monkey and pig-tailed macaque BOB by one amino acid.

Target Antigen

G-protein coupled receptor 15

Target

GPR15/BOB

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, ICC

Field of Research

Infectious Disease

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Additionnal Information

Immunoblotting: use at 1:500-1:2,000 dilution. <br><br>Positive control: Jurkat or A549 cell lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes GPR15/BOB of human, mouse, and rat (50 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1, and V28 have been recently identified as HIV co-receptors. The genes encoding human and monkey GPR15/BOB (for G protein- coupled receptor 15 and brother of Bonzo) have been cloned. This novel g protein- coupled receptor serves as co-receptor for SIV and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 is under investigation.