SIRT4-IN-1
SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms[1].
Product Specifications
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sirt4-in-1.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=C(N1)SCC(NC3=NC=C(S3)S(C4=CC=C(C=C4)[N+]([O-])=O)(=O)=O)=O)C=CC=C2
Molecular Formula
C19H13N5O6S3
Molecular Weight
503.53
References & Citations
[1]Martin Pannek, et al. Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. J Med Chem. 2024 Feb 8;67 (3) :1843-1860.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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