Pifithrin-β (hydrobromide)

Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.

Product Specifications

CAS Number

511296-88-1

Product Name Alternative

PFT β (hydrobromide) ; Cyclic Pifithrin-α (hydrobromide)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ferroptosis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pifithrin-_beta_-hydrobromide.html

Purity

99.97

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1.Br

Molecular Formula

C16H17BrN2S

Molecular Weight

349.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19 (5) :1649-57.|[2]Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation productpifithrin-β. Life Sci. 2011 Apr 25;88 (17-18) :774-83.|[3]Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5 (5) :390-9.