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1- (2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl) thymine 3'-CE phosphoramidite

1- (2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl) thymine 3'-CE phosphoramidite is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1].

Product Specifications

CAS Number

208193-48-0

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-2-deoxy-5-o-dmt-2-fluoro-b-d-arabinofuranosyl-thymine-3-ce-phosphoramidite.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(C(C)=C1)=O)N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H]2F

Molecular Formula

C40H48FN4O8P

Molecular Weight

762.80

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16 (9) :7980-93.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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