4-PPBP (maleate)

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

Product Specifications

CAS Number

[201216-39-9]

UNSPSC

12352005

Target

IGluR; Sigma Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-ppbp-maleate.html

Purity

99.99

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C\C(O)=O.N1(CCCCC2=CC=CC=C2)CCC(C3=CC=CC=C3)CC1

Molecular Formula

C25H31NO4

Molecular Weight

409.52

References & Citations

[1]Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282 (1) :326-338.|[2]Takahashi H, et al. PPBP [4-phenyl-1- (4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27 (11) :2120-2123.|[3]Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59 (6) :416-424.