4-PPBP (maleate)
Product Specifications
UNSPSC Description
4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].
Target Antigen
iGluR; Sigma Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-ppbp-maleate.html
Purity
99.63
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C\C(O)=O.N1(CCCCC2=CC=CC=C2)CCC(C3=CC=CC=C3)CC1
Molecular Weight
409.52
References & Citations
[1]Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338.|[2]Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123.|[3]Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101043/4-PPBP-maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101043/4-PPBP-maleate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
201216-39-9
Available Sizes
Curated Selection
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