ML-323

ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.

Product Specifications

CAS Number

[1572414-83-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML-323.html

Concentration

10mM

Purity

99.51

Solubility

DMSO : ≥ 49 mg/mL

Smiles

CC1=CN=C(C2=C(C(C)C)C=CC=C2)N=C1NCC3=CC=C(N4N=NC=C4)C=C3

Molecular Formula

C23H24N6

Molecular Weight

384.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10 (4) :298-304.|[2]Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.