Sacituzumab tirumotecan
Sacituzumab tirumotecan (SKB264/MK-2870) is a TROP2 ADC. The internalization and anti-tumor activity of Sacituzumab tirumotecan are enhanced in tumor cell lines with EGFR mutations. Sacituzumab tirumotecan can be used in the research of triple negative breast cancer (TNBC), non small cell lung cancer (NSCLC) and other cancers[1][2].
Product Specifications
CAS Number
2768350-77-0
Product Name Alternative
SKB264; MK-2870
UNSPSC
12352203
Target
Antibody-Drug Conjugates (ADCs) ; TROP2
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sacituzumab-tirumotecan.html
Purity
99.63
Smiles
[Sacituzumabtirumotecan]
Molecular Weight
157907 (average)
References & Citations
[1]Xu B, et, al. Sacituzumab tirumotecan (SKB264/MK-2870) in patients (pts) with previously treated locally recurrent or metastatic triple-negative breast cancer (TNBC) : Results from the phase III OptiTROP-Breast01 study. Special Clinical Science Symposia. May 29, 2024.|[2]Fang W, et al. Sacituzumab tirumotecan versus docetaxel for previously treated EGFR-mutated advanced non-small cell lung cancer: multicentre, open label, randomised controlled trial[J]. bmj, 2025, 389.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
ADC Related
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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