ABT-770
ABT-770 (compound 11) is a highly selective and orally active MMP inhibitor, demonstrating over 1000-fold selectivity for MMP-2 (IC50=4 nM) compared to MMP-1 (IC50=4600 nM) . ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis[1].
Product Specifications
CAS Number
220614-50-6
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abt-770.html
Smiles
O=CN([C@@H](CN(C(NC1(C)C)=O)C1=O)COC2=CC=C(C3=CC=C(OC(F)(F)F)C=C3)C=C2)O
Molecular Formula
C22H22F3N3O6
Molecular Weight
481.42
References & Citations
[1]Curtin, et al. "Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770." Bioorganic & medicinal chemistry letters 11.12 (2001) : 1557-1560.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-2
Frequently Asked Questions
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