ABT-770

ABT-770 (compound 11) is a highly selective and orally active MMP inhibitor, demonstrating over 1000-fold selectivity for MMP-2 (IC50=4 nM) compared to MMP-1 (IC50=4600 nM) . ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis[1].

Product Specifications

CAS Number

[220614-50-6]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abt-770.html

Smiles

O=CN([C@@H](CN(C(NC1(C)C)=O)C1=O)COC2=CC=C(C3=CC=C(OC(F)(F)F)C=C3)C=C2)O

Molecular Formula

C22H22F3N3O6

Molecular Weight

481.42

References & Citations

[1]Curtin, et al. "Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770." Bioorganic & medicinal chemistry letters 11.12 (2001) : 1557-1560.