Pleiotrophin (Human)

<strong>Pleiotrophin (Human)</strong> <strong>Catalog number:</strong> MDP0706 <strong>CAS Number: </strong>26305-03-3 <strong>Sequence: </strong>Gly-Lys-Lys-Glu-Lys-Pro-Glu-Lys-Lys-Val-Lys-Lys-Ser-Asp-Cys-Gly-Glu-Trp-Gln-Trp-Ser-Val-Cys-Val-Pro-Thr-Ser-Gly-Asp-Cys-Gly-Leu-Gly-Thr-Arg-Glu-Gly-Thr-Arg-Thr-Gly-Ala-Glu-Cys-Lys-Gln-Thr-Met-Lys-Thr-Gln-Arg-Cys-Lys-Ile-Pro-Cys-Asn-Trp-Lys-Lys-Gln-Phe-Gly-Ala-Glu-Cys-Lys-Tyr-Gln-Phe-Gln-Ala-Trp-Gly-Glu-Cys-Asp-Leu-Asn-Thr-Ala-Leu-Lys-Thr-Arg-Thr-Gly-Ser-Leu-Lys-Arg-Ala-Leu-His-Asn-Ala-Glu-Cys-Gln-Lys-Thr-Val-Thr-Ile-Ser-Lys-Pro-Cys-Gly-Lys-Leu-Thr-Lys-Pro-Lys-Pro-Gln-Ala-Glu-Ser-Lys-Lys-Lys-Lys-Lys-Glu-Gly-Lys-Lys-Gln-Glu-Lys-Met-Leu-Asp (Disulfide bonds between Cys15-Cys44, Cys23-Cys53, Cys30-Cys57, Cys67-Cys99, and Cys77-Cys109) <strong>Amount:</strong> 50 ug <strong>Molecular Weight:</strong> 15302.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Wang X. Pleiotrophin: Activity and mechanism Adv Clin Chem. 2020;98:51-89. 2: Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W, Dai J, Hu Y. Deciphering the endometrial niche of human thin endometrium at single-cell resolution Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2115912119. 3: Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 Jul;22(7):1089-1098. 4: Liu Z, Yan M, Lei W, Jiang R, Dai W, Chen J, Wang C, Li L, Wu M, Nian X, Li D, Sun D, Lv X, Wang C, Xie C, Yao L, Wu C, Hu J, Xiao N, Mo W, Wang Z, Zhang L. Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling J Clin Invest. 2022 Apr 1;132(7):e155096. 5: Shi Y, Ping YF, Zhou W, He ZC, Chen C, Bian BS, Zhang L, Chen L, Lan X, Zhang XC, Zhou K, Liu Q, Long H, Fu TW, Zhang XN, Cao MF, Huang Z, Fang X, Wang X, Feng H, Yao XH, Yu SC, Cui YH, Zhang X, Rich JN, Bao S, Bian XW. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth Nat Commun. 2017 Jun 1;8:15080. 6: Knudsen AM, Halle B, Cédile O, Burton M, Baun C, Thisgaard H, Anand A, Hubert C, Thomassen M, Michaelsen SR, Olsen BB, Dahlrot RH, Bjerkvig R, Lathia JD, Kristensen BW. Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors Neuro Oncol. 2022 Jul 1;24(7):1074-1087. 7: Lee DH, Jin CL, Kim Y, Shin MH, Kim JE, Kim M, Lee MJ, Cho S. Pleiotrophin is downregulated in human keloids Arch Dermatol Res. 2016 Oct;308(8):585-91. 8: Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors Immunity. 2017 Dec 19;47(6):1100-1113.e6. 9: Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Tsaktanis T, Naumann U, Rothhammer V. Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation Front Immunol. 2022 Jan 3;12:800128. <a href="https://pubmed.ncbi.nlm.nih.gov/24516627">10: Bouderlique T, Henault E, Lebouvier A, Frescaline G, Bierling P, Rouard H, Courty J, Albanese P, Chevallier N. Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis PLoS One. 2014 Feb 7;9(2):e88287. </a> <br><strong>Products Related to Pleiotrophin (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>