Thioperamide
Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM[1].
Product Specifications
CAS Number
106243-16-7
Product Name Alternative
MR-12842
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/thioperamide.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(N1CCC(C2=CN=CN2)CC1)NC3CCCCC3
Molecular Formula
C15H24N4S
Molecular Weight
292.44
References & Citations
[1]J M Arrang, et al. Highly Potent and Selective Ligands for Histamine H3-receptors. Nature. 1987 May 14-20;327 (6118) :117-23.|[2]Na Wang, et al. Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments. Front Pharmacol. 2020 Jan 21;10:1583.|[3]Y Charlier, et al. Differential Effects of Histamine H (3) Receptor Inverse Agonist Thioperamide, Given Alone or in Combination With the N-methyl-d-aspartate Receptor Antagonist Dizocilpine, on Reconsolidation and Consolidation of a Contextual Fear Memory in Mice. Neuroscience. 2011 Oct 13;193:132-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
041158-APC 200 µL
RNPEP, ID (RNPEP, APB, Aminopeptidase B, Arginine aminopeptidase, Arginyl aminopeptidase) (APC) discontinued
Sign In for Pricing
View Details 
MBS452234-01 48 Tests
Mouse Growth Differentiation Factor 2 (GDF2) ELISA Kit
Sign In for Pricing
View Details MBS452234-02 96 Tests
Mouse Growth Differentiation Factor 2 (GDF2) ELISA Kit
Sign In for Pricing
View Details