Annexin A1 Polyclonal Antibody

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells.Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton.Has high affinity for Ca2+ and can bind up to eight Ca2+ ions. Displays Ca2+-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton.

ANX; Annexin I (lipocortin I) ; AnnexinA1; AnnexinI; ANX 1; ANX A1; ANXA 1; ANXA1 protein; CalpactinII; Chromobindin9; HGNC:533; Lipocortin 1; lipocortin I; ANX1; LPC1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35; Lipocortin1; LipocortinI; LPC 1; LPC; ANXA; Annexin A; ANXA1; ANX1; LPC1; Annexin 1; Calpactin 2; Chromobindin 9; Annexin-1; Chromobindin-9; p35; Calpactin-2; Annexin A1; Annexin I; Calpactin II; Lipocortin I; Phospholipase A2 Inhibitory Protein