TLR4 Antibody (APC)
Rabbit polyclonal to TLR4 (APC) . The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5) . The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa..
Product Specifications
Product Name Alternative
ARMD10, CD284, TLR 4, TOLL, Toll like receptor 4
UniProt
O00206
Reactivity
Human, Mouse
Immunogen
Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4
Target
TLR4
Clonality
Polyclonal
Conjugation
APC
Field of Research
Immunology & Inflammation
Purification
Protein A Purified
Concentration
1 mg/ml
Dilution
WB (1:500), IHC (1:50)
Molecular Weight
75-80kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
Tested Applications
FACS, FC, ICC, IF, IHC, WB
NCBI Accession Number
NP_612564.1
Host or Source
Rabbit
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Entrez
7099
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