Clindamycin (hydrochloride monohydrate)

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs) . Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA) . Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) [1].

Product Specifications

CAS Number

[58207-19-5]

UNSPSC

12352005

Hazard Statement

H225-H303-H311-H315-H319-H331-H335-H370

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/clindamycin-hydrochloride-monohydrate.html

Solubility

10 mM in DMSO

Smiles

CCC[C@H]1CN(C)[C@H](C(N[C@]([C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)([H])[C@H](C)Cl)=O)C1.[H]Cl.[H]O[H]

Molecular Formula

C18H36Cl2N2O6S

Molecular Weight

479.46

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P308+P311-P361+P364-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17 (1) :38.