Trifluoperazine (dihydrochloride)

Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

Product Specifications

CAS Number

[440-17-5]

UNSPSC

12352005

Hazard Statement

H302, H319, H336, H341, H372, H410

Target

Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/trifluoperazine-dihydrochloride.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.Cl.Cl

Molecular Formula

C21H26Cl2F3N3S

Molecular Weight

480.42

Precautions

H302, H319, H336, H341, H372, H410

References & Citations

[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[2]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23 (1) :67-70.|[3]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004 (1) :CD003545.|[4]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54 (1) :20-22.|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15 (2) :149-160.