N-Fmoc-N, O-dimethyl-L-serine

N-Fmoc-N, O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2].

Product Specifications

CAS Number

[1569103-64-5]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-fmoc-n-o-dimethyl-l-serine.html

Purity

98.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC[C@@H](C(O)=O)N(C)C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Molecular Formula

C20H21NO5

Molecular Weight

355.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Yao G, et al. Efficient Synthesis and Stereochemical Revision of Coibamide A. J Am Chem Soc. 2015 Oct 28;137 (42) :13488-91.|[2]Tranter D, et al. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. ACS Chem Biol. 2020 Aug 21;15 (8) :2125-2136.