PARP1-IN-8

PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549[1].

Product Specifications

CAS Number

[836640-15-4]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp1-in-8.html

Purity

99.29

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(Cl)=C1)CCN(N=C(C2=CC=CC=C2)C3=C4C=CC=C3)C4=O

Molecular Formula

C23H18ClN3O2

Molecular Weight

403.86

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Almahli H, Hadchity E, Jaballah MY, Daher R, Ghabbour HA, Kabil MM, Al-Shakliah NS, Eldehna WM. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.