L-742001 (hydrochloride)

L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC90 of 4.3 μM for vRNP activity in HEK293T cells[1].

Product Specifications

CAS Number

[174605-64-2]

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-742001-hydrochloride.html

Purity

99.9

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

O=C(/C(O)=C/C(C1(CCN(CC1)CC2=CC=CC=C2)CC3=CC=C(C=C3)Cl)=O)O.Cl

Molecular Formula

C23H25Cl2NO4

Molecular Weight

450.35

Precautions

H302, H410

References & Citations

[1]Annelies Stevaert, et al. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. J Virol. 2013 Oct;87 (19) :10524-38.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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