L-742001 (hydrochloride)
L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC90 of 4.3 μM for vRNP activity in HEK293T cells[1].
Product Specifications
CAS Number
[174605-64-2]
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-742001-hydrochloride.html
Purity
99.9
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(/C(O)=C/C(C1(CCN(CC1)CC2=CC=CC=C2)CC3=CC=C(C=C3)Cl)=O)O.Cl
Molecular Formula
C23H25Cl2NO4
Molecular Weight
450.35
Precautions
H302, H410
References & Citations
[1]Annelies Stevaert, et al. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. J Virol. 2013 Oct;87 (19) :10524-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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