Z-FY-CHO

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2].

Product Specifications

CAS Number

[167498-29-5]

Product Name Alternative

Z-Phe-Tyr-CHO

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z-fy-cho.html

Concentration

10mM

Purity

96.18

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic)

Smiles

O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N[C@H](C=O)CC3=CC=C(O)C=C3)=O

Molecular Formula

C26H26N2O5

Molecular Weight

446.50

References & Citations

[1]Lingyun Li, et al. Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine. Biochem Biophys Res Commun. 2016 Feb 12;470 (3) :579-585.|[2]Qing-qing Zhang, et al. Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage. Acta Pharmacol Sin. 2015 Sep;36 (9) :1113-25.|[3]J T Woo, et al. Suppressive effect of N- (benzyloxycarbonyl) -L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. Eur J Pharmacol. 1996 Apr 4;300 (1-2) :131-5.