Elagolix sodium (Standard)

Elagolix sodium (Standard) is the analytical standard of Elagolix sodium. This product is intended for research and analytical applications. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.

Product Specifications

CAS Number

[832720-36-2]

Product Name Alternative

NBI-56418 sodium (Standard)

UNSPSC

12352005

Hazard Statement

H361

Target

GnRH Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/elagolix-sodium-standard.html

Smiles

O=C(CCCN[C@@H](CN(C1=O)C(N(C(C)=C1C2=CC=CC(OC)=C2F)CC3=C(C=CC=C3F)C(F)(F)F)=O)C4=CC=CC=C4)O[Na]

Molecular Formula

C32H29F5N3NaO5

Molecular Weight

653.57

Precautions

P280-P405-P501

References & Citations

[1]Kim SM, et al. Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist. J Med Chem. 2016 Oct 13;59 (19) :9150-9172. Epub 2016 Sep 27.|[2]Chen C, et al. Discovery of sodium R- (+) -4-{2-[5- (2-fluoro-3-methoxyphenyl) -3- (2-fluoro-6-[trifluoromethyl]benzyl) -4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem. 2008 Dec 11;51 (23) :7478-85.