Trovafloxacin (mesylate)
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3].
Product Specifications
CAS Number
147059-75-4
UNSPSC
12352005
Hazard Statement
H314, H361
Target
Antibiotic; Bacterial; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/trovafloxacin-mesylate.html
Purity
99.7600
Solubility
DMSO : 116.67 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])[C@H](N)[C@@]5([H])C4)=C(F)C=C3C1=O)O.CS(=O)(O)=O
Molecular Formula
C21H19F3N4O6S
Molecular Weight
512.46
Precautions
H314, H361
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Quinolone
Citation 01
Available Sizes
Frequently Asked Questions
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