CB-184

CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2].

Product Specifications

CAS Number

[165307-47-1]

UNSPSC

12352005

Target

Apoptosis; Sigma Receptor

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cb-184.html

Smiles

OC1=CC=CC([C@@]2(CCN3C)CC(/C([C@H]3C2)=C/C4=CC(Cl)=C(Cl)C=C4)=O)=C1

Molecular Formula

C22H21Cl2NO2

Molecular Weight

402.31

References & Citations

[1]Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18 (7) :938-49.|[2]Keith W Crawford, et al. sigma (2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443 (1-3) :207-9.