CB-184
CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2].
Product Specifications
CAS Number
165307-47-1
UNSPSC
12352005
Target
Apoptosis; Sigma Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cb-184.html
Smiles
OC1=CC=CC([C@@]2(CCN3C)CC(/C([C@H]3C2)=C/C4=CC(Cl)=C(Cl)C=C4)=O)=C1
Molecular Formula
C22H21Cl2NO2
Molecular Weight
402.31
References & Citations
[1]Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18 (7) :938-49.|[2]Keith W Crawford, et al. sigma (2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443 (1-3) :207-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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