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RO27-3225 (TFA)

Product Specifications

UNSPSC Description

RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].

Target Antigen

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro27-3225-tfa.html

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

Smiles

CCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N)=O)C)=O)CC1=CNC2=C1C=CC=C2)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O.O=C(O)C(F)(F)F

Molecular Weight

898.93

References & Citations

[1]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603.|[2]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.|[3]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P2242A/RO27-3225-TFA-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P2242A/RO27-3225-TFA-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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