RO27-3225 (TFA)

RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].

Product Specifications

CAS Number

[1373926-49-8]

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro27-3225-tfa.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CCCC(N[C@@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N(C)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C39H52N12O6.xC2HF3O2

Molecular Weight

784.91 (free base)

References & Citations

[1]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150 (5) :595-603.|[2]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.|[3]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20 (9) :3442-8.