Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

RO27-3225 (TFA)

Product Specifications

UNSPSC Description

RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].

Target Antigen

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro27-3225-tfa.html

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

Smiles

CCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N)=O)C)=O)CC1=CNC2=C1C=CC=C2)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O.O=C(O)C(F)(F)F

Molecular Weight

898.93

References & Citations

[1]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603.|[2]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.|[3]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P2242A/RO27-3225-TFA-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P2242A/RO27-3225-TFA-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MYEOV2 CRISPR Activation Plasmid (h)
sc-409378-ACT 20 µg

MYEOV2 CRISPR Activation Plasmid (h)

Ask
View Details
LV401 rabbit pAb
UB-GEN-9594 100 ul

LV401 rabbit pAb

Ask
View Details
LT4R2 Human Recombinant Protein, Synthetic Nanodisc
TP721708M 100 µg

LT4R2 Human Recombinant Protein, Synthetic Nanodisc

Ask
View Details
PIM3 Adenovirus (Human)
36698051 1.0 ml

PIM3 Adenovirus (Human)

Ask
View Details
MD-MINI Lid, L58.5 x W83 x H31.5 mm
MD-MINI-LID 1 Each

MD-MINI Lid, L58.5 x W83 x H31.5 mm

Ask
View Details
Biotin Linked Monoclonal Antibody to Prolactin (PRL)
MBS2131611-01 0.1 mL

Biotin Linked Monoclonal Antibody to Prolactin (PRL)

Ask
View Details