AFN-1252 (tosylate)

AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of 0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2].

Product Specifications

CAS Number

[1047981-31-6]

Product Name Alternative

API-1252 (tosylate) ; Debio 1452 (tosylate)

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/afn-1252-tosylate.html

Smiles

O=S(O)(C1=CC=C(C=C1)C)=O.CC2=C(CN(C)C(/C=C/C(C=C3CC4)=CNC3=NC4=O)=O)OC5=CC=CC=C25

Molecular Formula

C29H29N3O6S

Molecular Weight

547.62

References & Citations

[1]Nachum Kaplan, et al. In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics. J Chemother. 2013 Feb;25 (1) :18-25.|[2]Nachum Kaplan, et al. Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor. Antimicrob Agents Chemother. 2012 Nov;56 (11) :5865-74.