BRD4 ligand-Linker Conjugate 1 (TFA)
BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs[1][2].
Product Specifications
UNSPSC
12352005
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd4-ligand-linker-conjugate-1-tfa.html
Purity
98.66
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C2=NC3(CC3)C4=NN=C(C)N4C5=CC=C(C6=CN(CCCCCCN)N=C6)C=C25)C=C1.OC(C(F)(F)F)=O
Molecular Formula
C30H31ClF3N7O2
Molecular Weight
614.06
References & Citations
[1]Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20 (8) :1367-1377.|[2]Phillips AJ, et al. Preparation of bromodomain targeting degronimers for target protein degradation. World Intellectual Property Organization, WO2017197056 A1. 2017-11-16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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